Wed.Feb 22, 2023

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Stopping pharmacy benefit managers from “gaming the system”

PhRMA

People around the country say they are paying too much for their prescription medicines. State policymakers could help address this problem now. Doing so starts with stopping pharmacy benefit managers (PBMs) from taking advantage of the health system and patients.

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Recommendations Differ Between WHO and CDC for HPV Vaccine Schedules

Drug Topics

The World Health Organization (WHO) and the CDC recommend different doses when it comes to vaccine protection against the human papillomavirus (HPV).

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Trending Sources

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Patent wars: what’s behind Amgen’s possible win over Sanofi at the US Supreme Court

Pharmaceutical Technology

Amgen could be the winner of a high-stakes patent spat with Sanofi as tensions run high weeks before the March 27 US Supreme Court hearing. While some courts were previously on Sanofi’s side, it is possible that Amgen’s case could win this time, some legal experts say. However, Sanofi’s side also has significant support, highlighting the dispute’s contentious nature.

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Increase Seen in Eczema, Prevalence Varies by Race and Ethnicity

Drug Topics

Previous surveys suggested care disparities. Investigators compared these outcomes because of a lack of research in this space.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Tools to predict stroke risk work less well for Black patients, study finds

STAT

Stroke risk prediction tools are meant to guide how doctors approach a potentially deadly condition, using factors like heart disease and high blood pressure to get a handle on which patients might benefit from a particular treatment. For years, doctors have used several different algorithms to try to capture the true risk of stroke, including newer models that use machine learning.

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Moderna Plans to Offer Free COVID-19 Vaccine to Uninsured Patients

Drug Topics

More traditional health care coverage will begin when the U.S. public health emergency response to COVID-19 ends on May 11.

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More Trending

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Amazon completes $3.9B deal to acquire One Medical

Drug Store News

One Medical offers in-office and 24/7 virtual care services, on-site labs and programs for preventive care, chronic care management, common illnesses and mental health concerns.

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Hospital lobby urges FTC to withdraw or add healthcare exceptions to sweeping noncompete ban

Fierce Healthcare

Hospital lobby urges FTC to withdraw or add healthcare exceptions to sweeping noncompete ban dmuoio Wed, 02/22/2023 - 15:55

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12 health benefits of alpha-lipoic acid

The Checkup by Singlecare

Superfoods are touted for their health benefits because they’re jam-packed with vitamins, minerals, and antioxidants. You’ve likely heard about the power of vitamin C and vitamin E , but one just as potent antioxidant that is made in your very own mitochondria is alpha-lipoic acid. “ Alpha-lipoic acid is an antioxidant , a type of nutrient that has the ability to protect cells from damage,” explains Sony Sherpa , MD, a holistic physician from Nature’s Rise.

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Survey Finds 57% of U.S. Physicians Have Changed Their Perception of a Medication as a Result of Info on Social Media

PharmExec

Sermo and LiveWorld survey of 50+ pharma marketers and 200+ physicians finds that social media plays a major role in influencing perceptions of medications, prescribing Habits, ongoing medical education and professional networking.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Rare diseases, diversity, data and other big issues facing patient recruitment and retention - an interview with the founder and CEO of Andaman7

Outsourcing Pharma

Father and software engineer, Vincent Keunen combined his personal experience of leukemia and his son's bone cancer with his professional skills to provide all patients with a tool to manage their health information on their smartphone.

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FDA grants Fast Track status for Biohaven’s taldefgrobep alfa to treat SMA

Pharmaceutical Technology

The US Food and Drug Administration (FDA) has granted Fast Track designation for Biohaven ’s new anti-myostatin adnectin, taldefgrobep alfa, to treat spinal muscular atrophy (SMA). The new myostatin-targeting biologic investigational agent has been designed for specific binding to myostatin (GDF-8) to reduce overall levels of myostatin. It also works as a receptor antagonist to block myostatin signalling in skeletal muscles.

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Pfizer likely to be first to gain FDA approval for new RSV vaccine

Pharmafile

The FDA is expected to approve Pfizer’s new respiratory syncytial virus (RSV) vaccine this summer following its acceptance of the company’s fast-track license application for the new product. Pfizer’s jab is administered to pregnant women in the second or third trimester and can protect the infant from RSV, as antibodies triggered by the vaccine are passed on to the foetus, meaning they are protected against RSV from birth until they are around six months old.

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Flu shot provided relatively robust level of protection this year, data show

STAT

This year’s flu shot generated relatively robust levels of protection, new data show, with the vaccine’s effectiveness ranging between about 45% and 55%, depending on the age group and the metric studied, such as whether there was protection against any infection or infection that was severe enough to require hospitalization. The data were presented Wednesday to the Advisory Committee on Immunization Policy, which advises the Centers for Disease Control and Prevention.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Endotoxin trends: sustainability, automation and beyond

European Pharmaceutical Review

Bacterial endotoxin testing (BET) is key in pharmaceutical development/manufacturing, due to the potentially harmful effects that endotoxins can have on human health. 1 BET often utilises Limulus amoebocyte lysate (LAL), refined from the blood of the horseshoe crab, as an in vitro testing assay to detect bacterial endotoxins. 1 While the process was developed in the 1970s and 1980s, there have been several advances over the past few years, with drives to improve sustainability, increase testing

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Amazon closes $3.9B buyout of health company One Medical

STAT

NEW YORK — Amazon said Wednesday it has closed its $3.9 billion acquisition of the primary care organization One Medical. The e-commerce giant has said the buyout, which was  announced in July,  is a key component of its growing health care business, which includes its online drugstore Amazon Pharmacy and a patient to doctor messaging service called Amazon Clinic.

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Pharma Marketers Need AI Now: How to deliver a truly personalized, omnichannel experience for your patients, with William Grambley, CEO of Allazo Health

Pharma Marketing Network

Marketing in the era of consumer-driven healthcare requires new tools and techniques. If you want patients to initiate therapy, you need to connect across more channels, more personally, and in the ways consumers prefer to be engaged. Plus, given today’s budget realities, you’re likely being asked to achieve more with less. In this podcast, William Grambley, CEO of AllazoHealth, explains how pharma marketers can reach their omni-channel engagement objectives with artificial intelligence (AI), an

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STAT+: Charles River suspends shipments of monkeys used in research amid federal probe

STAT

Charles River Laboratories, one of the largest clinical research organizations in the U.S., is suspending shipments of non-human primates that are widely used in pharmaceutical research after receiving a subpoena from federal authorities probing a Cambodian smuggling ring. The move comes after several people — including two Cambodian wildlife officials — were indicted in November for their alleged involvement in the monkey-smuggling operation.

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Google Cloud, Redox team up to accelerate data interoperability for health plans, providers and digital health startups

Fierce Healthcare

Google Cloud, Redox team up to accelerate data interoperability for health plans, providers and digital health startups hlandi Wed, 02/22/2023 - 08:03

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Using alkali-metal cation recognition of ?-cyclodextrin to detect lithium ions by MALDI-TOF

European Pharmaceutical Review

Lithium (Li) is the third element in the periodic table that belongs to the group of alkali metals. It was discovered by Johann August Arfwedson in the early 1800s in the mineral petalite. This is thought to explain the origin of the element’s name; from lithos (Greek for stone). It is found as different salts such as sulphate, acetate and chloride.

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U.N.: Progress on reducing global maternal mortality has stalled since 2015

STAT

The progress the world has made in reducing maternal mortality has stalled in recent years, with some regions — including Europe and Northern America — backsliding since 2015, according to a new report from United Nations agencies. The report estimated that there were 287,000 maternal deaths globally in 2020, a slight decrease compared to an estimated 309,000 maternal deaths in 2016.

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PDA releases contamination control strategy report

European Pharmaceutical Review

The Parenteral Drug Association (PDA)’s long-awaited Technical Report 90: Contamination Control Strategy Development in Pharmaceutical Manufacturing is now available. Developing a contamination control strategy (CCS) According to the PDA, contamination control measures have been a core element of good manufacturing practices in pharmaceutical drug manufacturing for decades.

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Opinion: Use ‘racial privilege’ — not race — to measure and understand health

STAT

When I go to a health care provider and check “Black” for my race or ethnicity, it means that my provider — before even seeing me — knows I have dark skin and “different” hair. But the biases or stereotypes emanating from my answer could include assumptions that I have no husband, limited education, or earn a low income or none.

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Optimising fermentation with process analytical technology

European Pharmaceutical Review

Fermentation plays a key role in biotechnology and is vital to the manufacture of a wide range of products including vaccines, antibiotics and vitamins. The key to achieving maximum efficiency in any fermentation process is maintaining a precise environment for specific organisms to thrive. Analysing the respiratory gases being fed into and removed from the fermenter is an ideal and non-invasive way to do this, ie, monitoring and characterising physiological parameters of the procedure, such as

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STAT+: Once high-flying Rubius to shut down. Its flameout is a lesson for biotech

STAT

Rubius Therapeutics went public in 2018 at a $2 billion valuation — the largest biotech stock market debut at that time. On Wednesday, the company — battered down to a market value of $15 million — said it was shutting down and liquidating all of its remaining assets. The official end of Rubius marks one of biotech’s highest-profile flameouts.

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Indegene Launches Metaverse Capabilities

PharmExec

The capabilities will support life sciences organizations with a variety of use cases, including health care provider (HCP) interactions, HCP education, and patient education.

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STAT+: Moderna expands CRISPR gene editing research with ElevateBio partnership

STAT

Moderna is aiming to build a gene editing franchise powered by some of the same technologies used in its COVID-19 vaccines. The Cambridge biotech company announced Wednesday that it will partner with Life Edit Therapeutics to develop potentially permanent treatments for rare genetic diseases and other conditions. Life Edit is the North Carolina subsidiary of ElevateBio, a cell and gene therapy manufacturing firm in Waltham.

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Developing terminal sterilisation processes for oligonucleotide drugs

European Pharmaceutical Review

A new report has reviewed the present state of sterile oligonucleotide drug product processing. It includes recommendations to aid in the evaluation and development of terminal sterilisation processes, additionally exploring current regulatory expectations for oligonucleotide drugs. DeCollibus et al. identified that the two most common methods for sterilising parenteral drug products are terminal sterilisation (TS) and membrane sterilisation.

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Dermablend’s newest primer aims to leave skin looking refreshed

Drug Store News

Brilliant Base is an illuminating primer that works to brighten the skin, as well as leave it looking refreshed and moisturized for up to 24 hours.

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AstraZeneca BTK inhibitor tablet approved in EU for leukaemia

European Pharmaceutical Review

AstraZeneca’s tablet formulation of Calquence (acalabrutinib) has been approved in the European Union (EU) for adults with chronic lymphocytic leukaemia (CLL). Calquence is a selective inhibitor of Bruton’s tyrosine kinase (BTK). It binds covalently to BTK, inhibiting its activity. According to AstraZeneca, in B cells, BTK signalling results in activation of pathways necessary for B-cell proliferation, trafficking, chemotaxis and adhesion.

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STAT+: Pharmalittle: Lilly diabetes drug back on shelves after two-month shortage; AbbVie sued for human rights violations over Humira pricing

STAT

Rise and shine, everyone. The middle of the week is upon us. Have heart, though. You made it this far, so why not hang on for another couple of days, yes? And what better way to make the time fly than to keep busy. So grab that cup of stimulation — our flavor today is mocha marshmallow — and get started. Meanwhile, do keep us in mind if you hear anything saucy.

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Analytical Techniques In-Depth Focus 2023

European Pharmaceutical Review

New workflow for the analysis of mRNA therapeutics Here, Mark Dickman, Professor in Bioanalytical Science and Engineering at the University of Sheffield, explores how analytical techniques such as liquid chromatography-mass spectrometry can support the manufacturing of mRNA therapeutics. Computed tomography for in-depth investigation of freeze-dried products In this article, Teresa Siegert and Henning Gieseler, discuss the benefits of applying computed tomography in the production of freeze-drie

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Eight essential steps for patient engagement, recruitment and retention

Outsourcing Pharma

Patient engagement, recruitment and retention are critical to achieving a successful clinical trial.

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Gilead, Teva and J&J's HIV antitrust case inches closer to trial as judge keeps most claims on the table

Fierce Pharma

Gilead, Teva and J&J's HIV antitrust case inches closer to trial as judge keeps most claims on the table zbecker Wed, 02/22/2023 - 14:40

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