Mon.Oct 17, 2022

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Biosimilar uptake is increasing and so are health savings

PhRMA

There has been a lot of talk recently about the biosimilars marketplace and what role biosimilars play in reducing health care costs. We’re here to set the record straight about how these medicines are reshaping America’s health care landscape and improving patient and provider choice.

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Cancer Vaccine May be Effective for Melanoma Patients

Pharmacy Times

A researcher suggests that novel immune modulating cancer therapies like cancer vaccines can be more effective and safer alternative to previous cancer immunotherapies.

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Trending Sources

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Boston University researchers’ testing of lab-made version of Covid virus draws government scrutiny

STAT

Research at Boston University that involved testing a lab-made hybrid version of the SARS-CoV-2 virus is garnering heated headlines alleging the scientists involved could have unleashed a new pathogen. There is no evidence the work, performed under biosecurity level 3 precautions in BU’s National Emerging Infectious Diseases Laboratories, was conducted improperly or unsafely.

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Artificial Intelligence is Changing the Face of Pharmacovigilance

Pharmacy Times

Pharmaceutical companies are looking into AI as the new method to not only reduce research and development costs, but also prevent costly errors.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Drug-related Deaths in Older Adults on the Rise

Drug Topics

Two reports show that drug-related deaths are skyrocketing among people 65 years and older.

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Hepatitis B Infection Risk May Be Higher for Males

Pharmacy Times

Males are more likely to suffer from the sexual dimorphism of hepatitis B infection, suggesting that sex hormones have a role in complication risk.

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More Trending

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Chronic Kidney Disease Rates in People with Diabetes Considered "Troubling"

Drug Topics

An analysis of data from more than 640,000 people with diabetes recorded between 2015-2020 is providing new insight into what study investigators are calling "troubling" trends in the incidence of CKD in the face a growing diabetes epidemic.

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CHMP recommends Pluvicto® for treating advanced prostate cancer

European Pharmaceutical Review

Novartis announced that The European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use (CHMP) has recommended granting a marketing authorisation for Pluvicto ® radioligand therapy for treatment of patients with prostate cancer. Pluvicto combines a targeting compound (ligand, in this case directed to PSMA) with a therapeutic radioisotope (in this case lutetium-177).

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STAT+: What to know about Roche’s experimental Alzheimer’s treatment

STAT

The next big Alzheimer’s disease study readout is almost here. Roche is nearing the completion of a pair of clinical trials involving its experimental treatment called gantenerumab. The Swiss pharma giant will announce results from the studies within the next six weeks.

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Significant Improvement in Atrial Fibrillation Detection Found with At-Home Cardiac Monitoring

Drug Topics

US Preventive Services Task Force hasn't endorsed screening for atrial fibrillation. Findings from these two studies might factor into a reconsideration.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Opinion: UpToDate has a racism problem. Its name is Dr. Stanley Goldfarb

STAT

The University of Pennsylvania’s Division of Renal-Electrolyte and Hypertension recently made a quiet update to its history web page : it removed all references to its former co-chief, Dr. Stanley Goldfarb. For several years, Goldfarb has been a vocal critic of considering social determinants of health, racism, and anything else he considers too “woke” in medical education or health care at large.

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Bayer extends elinzanetant trials to include breast cancer

pharmaphorum

Bayer has added another clinical trial to its extensive phase 3 programme for oral neurokinin antagonist elinzanetant, hoping to show that it can treat vasomotor symptoms (VMS) in breast cancer patients. Elinzanetant is already being tested in the OASIS trials for VMS associated with menopause – an indication in which Bayer is in a head-to-head race with Astellas and its fezolinetant drug candidate – and breast cancer could represent a sizeable additional patient population for the drug.

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Justice Department sues Cigna for allegedly exaggerating conditions of Medicare Advantage members

STAT

The Department of Justice filed a new lawsuit against Cigna Monday, alleging the health insurance company overcharged the federal government by purposefully inflating how sick its Medicare Advantage members were. The decision is a change of heart from federal prosecutors, who originally declined to intervene in the whistleblower case back in 2020.

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Bringing the promise of immunotherapy to a broader population

pharmaphorum

When James P Allison and Tasuku Honjo were awarded the Nobel Prize for Medicine in 2018 for their discovery of cancer therapy through inhibition of negative immune regulation, it shone a light on decades of research into recruiting the immune system to fight cancer. Their success led to the discovery of an entirely new principle for cancer therapy – the field of immuno-oncology – one that is now a mainstay of cancer treatment, changing the way these diseases can be managed.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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STAT+: Milestone Pharma’s nasal spray rapidly restores normal heart rhythm, achieving goal of key study

STAT

Milestone Pharmaceuticals said Monday that an experimental nasal-spray medicine acted quickly to treat people experiencing episodes of a rapid but non-fatal heart rate — more than doubling the conversion to normal heart rhythm and achieving the primary goal of a late-stage clinical trial. The medicine, called etripamil , is meant to treat people with paroxysmal supraventricular tachycardia, or PSVT, a condition characterized by episodes of rapid heartbeat that suddenly start and stop.

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Expert: Pharmacists are Advocates for Patients, Simplifying the Health Care System

Pharmacy Times

As part of American Pharmacist Month, Pharmacy Times is asking experts what they believe the value of the pharmacist is.

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STAT+: Josh Bilenker’s last biotech sold for $8 billion. His next one is cloaked in mystery but loaded with money

STAT

Josh Bilenker’s last company, Loxo Oncology, was purchased by Eli Lilly for $8 billion. No surprise, then, that his next effort has already raised at least $473 million in funding from private investors even before telling the public what, exactly, it is working on. Treeline Biosciences, the new venture by Bilenker and Jeffrey Engelman, formerly Novartis’s top cancer researcher, has hired more than 130 people across three research sites in little more than a year, according to a co

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European Pharmaceutical Review Issue 5 2022

European Pharmaceutical Review

Included in this issue: PATENTS. Patents: a necessary evil? David Elder, David P Elder Consultancy. MICROBIOLOGY. Pharma’s green mission: trends in bacterial endotoxin testing. Hannah Balfour. Lindsey Silva, Carmen Marín Delgado de Robles, Viviane Grunert da Fonseca and Evelyn Der, Roche Group. QA/QC. An Annex 1 and Pharma 4.0 perspective on water quality.

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He helped discover BMS’s psoriasis pill Sotyktu. Here’s what he has to say about early science in Big Pharma

PharmaVoice

Bristol Myers Squibb’s senior principal scientist Ryan Moslin shares why his team was built for success and how they ushered a potential psoriasis blockbuster through discovery.

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Novo Nordisk acquires Forma Therapeutics for $1.1bn

Pharmaceutical Technology

Novo Nordisk has concluded the acquisition of all outstanding shares of common stock of clinical-stage biopharmaceutical company Forma Therapeutics for $20 for each share in cash or a deal totalling $1.1bn. In September, Novo Nordisk entered a definitive agreement to acquire Forma. With the conclusion of the merger, Forma became Novo Nordisk’s fully-owned subsidiary. .

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Dr. Brett Giroir to receive 2022 Excellence in Patient Care Award at NACDS Foundation Dinner

Drug Store News

Former Assistant Secretary for Health in the Department of Health and Human Services and member of the White House Coronavirus Task Force demonstrated tremendous leadership on the front lines of the COVID-19 response.

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How Can I Become a Certified Nurse-Midwife? 

Board Vitals - Pharmacist

A Certified Nurse-Midwife (CNM) is a healthcare provider that delivers care to women throughout all stages of their lives. While they are similar in some ways to Labor & Delivery nurses (L&D) and OBGYNs, CNMs have a unique role in the lives of women. What is a Certified Nurse-Midwife, and what steps do you need to take to become a CNM? What is the Role of a Certified Nurse-Midwife?

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Omicron BA.4/BA.5-adapted bivalent vaccine generates higher antibody response

Hospital Pharmacy Europe

The Omicron BA.4/BA.5-adapted-bivalent COVID-19 vaccine demonstrated a substantial increase in antibody response above pre-booster levels. The Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine showed a substantial increase in neutralising antibody response according to a press release by the joint manufacturers Pfizer and BioNTech. The findings come from a Phase 2/3 clinical trial evaluating the safety, tolerability, and immunogenicity of the companies’ bivalent vaccine.

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STAT+: Pharmalittle: BioNTech eyes cancer vaccine before decade’s end; Pfizer asks Supreme Court to review copay programs

STAT

Good morning, everyone, and welcome to another working week. We hope the weekend respite was relaxing and invigorating, because that all-too-predictable routine of online meetings, calls, and deadlines has returned. But what can you do? The world, such as it is, keeps spinning. So time to give it a nudge in a better direction by firing up the coffee kettle to brew another cup of stimulation.

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CHMP recommends dengue vaccine for children

European Pharmaceutical Review

The European Medicines Agency’s human medicines committee ( CHMP ) has recommended the use of Takeda’s Dengue Tetravalent Vaccine (live, attenuated), to prevent disease caused by dengue virus serotypes 1, 2, 3 and 4 in people from four years of age to 45+. This recommendation marks the first time the CHMP has simultaneously reviewed applications for EU-aimed medicine under both the centralised procedure and the EMA’s ‘EU-Medicines for all’ (EU-M4all) programme for non-EU countries.

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STAT+: Despite its threats, PhRMA is still supporting Democrats who voted for Medicare negotiation

STAT

Drugmakers’ powerhouse lobby did not exactly make good on its early August threat to hold Democrats “accountable” this fall after the caucus voted to let the government negotiate drug prices. The Pharmaceutical Research and Manufacturers of America’s political action committee put $2,000 towards the New Democrat Coalition Action Fund on Aug. 22, just weeks after every member voted for the sweeping Inflation Reduction Act that includes an unprecedented move to let the

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Enterin and Parkinson’s UK to partner on dementia study

European Pharmaceutical Review

US biopharma company Enterin Inc. and Parkinson’s UK’s drug development and discovery division, Parkinson’s Virtual Biotech , will collaborate on a new Phase II trial to study the effects of the drug ENT-01 on Parkinson’s Disease (PD)-associated dementia. . The partnership will build on research from Enterin’s randomised, placebo-controlled Phase II trial earlier this year.

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Prevent, Identify Periodontal Disease for Overall Patient Health

Pharmacy Times

Integrating an oral hygiene regimen into patients’ daily routines is essential to overall well-being.

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Happy National Pharmacy Week!

OctariusRx

Happy Pharmacy Week to all our team members and colleagues! Each year during the third full week in October, we celebrate National Pharmacy Week and I’d like to take the time to thank our Consultant Pharmacists, as well as supporting team members. Thank you for working so hard on behalf of all our clients and patients. Your hard work enhances patient safety and patient’s lives.

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US spends $290m stocking up on anti-radiation drug

Outsourcing Pharma

US government agrees a deal with Amgen for the supply of Nplate, which is used to treat blood cell injuries due to radiation.

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Sanofi to sell Japanese manufacturing plant

European Pharmaceutical Review

Sanofi has signed definitive agreements with Adragos Pharmaceutical, a German contract development and manufacturing organisation (CDMO), for the sale of its pharmaceutical manufacturing site in Kawagoe, Japan. The French pharmaceutical company will also enter into a long-term supply agreement with the CDMO. The goal is for the CDMO to become a strategic partner to introduce new European, North American and Japanese customers to the manufacturing plant.

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Albertsons reports strong Q2 results

Drug Store News

The retailer’s net income during the second quarter was $342.7 million compared to $295.2 million during the prior year.

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Conference Preview: IDWeek 2022

Drug Topics

IDWeek is taking place in person for the first time in 3 years.

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Nutrabolt’s C4 revamps pre-workout brand

Drug Store News

C4 updated its packaging design and launched two pre-workouts for athletes — C4 SuperSport and C4 Ripped SuperSport.