Rybelsus alternatives: What can I take instead of Rybelsus?

In this article:

• Compare Rybelsus alternatives
• Ozempic
• Mounjaro
• Victoza
• Bydureon BCise
• Natural alternatives to Rybelsus
• How to switch meds

In this article

• Compare Rybelsus alternatives
• Ozempic
• Mounjaro
• Victoza
• Bydureon BCise
• Natural alternatives to Rybelsus
• How to switch meds

Rybelsus, known generically as semaglutide, marks its place in Type 2 diabetes treatment plans as a daily oral medication that helps manage blood sugar (glucose) levels in adults. It belongs to a class of drugs called GLP-1 agonists, which work by mimicking a natural hormone that increases insulin release. Insulin regulates glucose levels by allowing sugar to enter cells for energy use. 

Although Rybelsus is a daily pill that can be a key player in controlling diabetes, some people might seek alternative options for various reasons. For example, they might experience bothersome side effects or have an allergic reaction to the active ingredient in Rybelsus. In other cases, they might find it hard to remember to take a daily pill or have other concerns.

Fortunately, there are several alternatives to Rybelsus. Read on to learn about different options you can discuss with a healthcare provider.

What can I take in place of Rybelsus?

There is a wide range of treatment options for Type 2 diabetes, and what may be effective for one person may not be for another. Medications for Type 2 diabetes may work in different ways, though they share similar treatment goals of managing blood sugar levels. In addition, they may have different costs and side effects. 

Ozempic contains the same active ingredient of Rybelsus in a weekly injectable form and is a viable Rybelsus alternative. Other alternatives to Rybelus include other GLP-1 agonists, such as Mounjaro (tirzepatide) and Victoza (liraglutide). Different drug classes may be used as alternatives to Rybelsus, including sulfonylureas, DPP-4 inhibitors, SGLT2 inhibitors, thiazolidinediones, and meglitinides. These alternatives may offer different mechanisms of action and could provide benefits that align more closely with a patient’s health needs.

Keep in mind that while Rybelsus may be used to manage weight loss in people who are overweight or obese, this is considered an off-label use. In other words, Rybelsus has been shown to promote weight loss but is not currently FDA-approved for this use. Other diabetes medications may boost weight loss as an FDA-approved or off-label use. 

Below is a table with common alternatives to Rybelsus, detailing brand and generic names, uses, dosage, and savings options.

Other alternatives to Rybelsus

• Glucotrol XR (glipizide extended release)
• Janumet (sitagliptin/metformin)
• Janumet XR (sitagliptin/metformin ER)
• Tradjenta (linagliptin)
• Onglyza (saxagliptin)
• Invokamet (canagliflozin/metformin)
• Invokamet ER (canagliflozin/metformin ER)
• Synjardy (empagliflozin/metformin)
• Synjardy XR (empagliflozin/metformin ER)
• Glyxambi (empagliflozin/linagliptin)
• Trijardy XR (empagliflozin/linagliptin/metformin ER)
• Steglatro (ertugliflozin)
• Steglujan (ertugliflozin/sitagliptin)

Top 5 Rybelsus alternatives

The following are some of the most common alternatives to Rybelsus.

1. Ozempic (semaglutide)

Both Rybelsus and Ozempic are GLP-1 agonists that work by increasing insulin production and lowering glucagon secretion, which help to control blood sugar levels. In addition to treating Type 2 diabetes, Ozempic can also help reduce the risk of heart attacks and strokes in people with Type 2 diabetes and heart disease. 

Like Rybelsus, Ozempic contains the active ingredient semaglutide. However, Ozempic is a subcutaneous injection taken once weekly instead of an oral tablet taken daily. Rybelsus and Ozempic may cause similar gastrointestinal side effects, such as nausea, vomiting, and diarrhea.

2. Trulicity (dulaglutide)

Trulicity, known by its generic name dulaglutide, is a medication for managing Type 2 diabetes. It belongs to a class of drugs called GLP-1 receptor agonists, similar to Rybelsus. Patients typically use Trulicity once a week by subcutaneous injection, and it may have side effects ranging from mild, such as nausea, to more severe allergic reactions. 

Unlike Rybelsus, which is taken orally, Trulicity is given as an injection, offering an alternative for those who might have difficulties with pills. Trulicity is approved for adults and children over 10 with Type 2 diabetes, while Rybelsus is only approved for adults. Trulicity can also help lower cardiovascular risks, which can be an added benefit for those with Type 2 diabetes and existing heart concerns. 

3. Mounjaro (tirzepatide)

Mounjaro, known by its generic name tirzepatide, is a relatively new medication for the management of Type 2 diabetes. While Rybelsus activates GLP-1 receptors to regulate blood sugar, Mounjaro works with a dual-action approach, targeting both GLP-1 and GIP receptors. As a result, Mounjaro may be more effective in long-term blood sugar control and weight loss. Mounjaro is typically administered as a once-weekly injection, contrasting with Rybelsus, which is taken orally. Compared to other GLP-1 agonists, Mounjaro is not approved to reduce cardiovascular risks in people with heart disease. 

4. Victoza (liraglutide)

Victoza contains the active ingredient liraglutide, which belongs to the same drug class as Rybelsus. It is typically prescribed to adults and children over 10 with Type 2 diabetes. Victoza is typically administered through daily injections, unlike Rybelsus, which comes in an oral tablet form. 

While both medications are prescribed for managing Type 2 diabetes, Victoza may also support cardiovascular health in patients with heart disease. Specifically, Victoza is FDA-approved to reduce the risk of heart attacks and strokes in people with heart disease and Type 2 diabetes. 

5. Bydureon BCise (exenatide)

Bydureon BCise is an injectable medication prescribed for managing blood sugar levels in individuals with Type 2 diabetes. Like Rybelsus, it is a GLP-1 receptor agonist. However, Bydureon BCise is administered as a weekly injection instead of a daily pill. Although it may require less frequent dosing, it also introduces the potential for injection site reactions, something not seen with Rybelsus. One downside is that it doesn’t offer additional benefits of reducing cardiovascular risks in people with heart disease. 

The choice between Rybelsus and prescription alternatives may depend on patient-specific factors, including how well a medication is tolerated and any relevant underlying health conditions or preferences.

Natural alternatives to Rybelsus

While Rybelsus is an approved medication to manage Type 2 diabetes, individuals may seek natural alternatives that can complement prescription medications. 

Diet and Exercise

A healthy diet and increasing physical activity are fundamental to managing Type 2 diabetes. A diet rich in fibrous vegetables, whole grains, and lean proteins may support stable blood glucose levels. In addition, consistent exercise helps improve insulin sensitivity and can lead to better blood sugar control.

Berberine

Berberine is a compound found in several plants that has been studied for its potential to help regulate blood sugar. Studies show that berberine supplements can significantly improve blood sugar levels and reduce inflammation in adults. In one meta-analysis, the supplement lowered fasting blood glucose by an average of 0.77 units and reduced key inflammation markers such as C-reactive protein by up to 62%.

Curcumin

Curcumin, the active ingredient in turmeric, has properties that may benefit blood glucose control. One study reviewed 16 research papers and found that curcumin, a compound in Curcuma longa, can effectively manage diabetes by reducing oxidative stress and inflammation. It significantly lowers fasting blood sugar, glycated hemoglobin (a marker of long-term blood sugar control), and body weight. However, the extent of its effectiveness will vary among individuals.

Cinnamon

Cinnamon is more than just a spice; it contains compounds that might improve insulin sensitivity. Some clinical trials suggest that cinnamon can help lower blood sugar levels, although its impact is not as pronounced as that of prescription drugs. Cinnamon should be viewed as a supplementary treatment rather than a primary therapy.

Always consult a healthcare provider before taking a dietary supplement for diabetes, especially if you take other medications. 

How to switch to a Rybelsus alternative

If you’re considering a switch from Rybelsus, you should first consult your healthcare provider. Your healthcare provider can provide medical advice based on your overall treatment plan.

For those ready to transition to an alternative to Rybelsus:

• Do not abruptly stop taking Rybelsus without guidance from your healthcare provider.
• Consult a healthcare provider to understand the timeline for switching medications and to minimize risks of side effects.
• Ensure a follow-up plan is in place to monitor blood glucose levels after the switch.

You can discuss factors like the effectiveness of an alternative medication in lowering blood sugar levels and the potential for allergic reactions with your healthcare provider. Some alternatives may have few side effects, while others may have more serious side effects.

Insurance plans can also influence the choice of medication. Checking in advance with your insurance company about coverage may save unforeseen expenses.