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Adderall XR generic availability, cost, and dosage

Generic Adderall XR has been available since 2012. Compare Adderall XR vs. generic amphetamine-dextroamphetamine ER.
Gerardo Sison medical writer headshot
By | Updated on May 9, 2025
Rx pill bottle: Adderall XR generic availability, cost, and dosage

Key takeaways

  • Adderall XR, approved by the FDA in 2001 for ADHD, contains amphetamine salts in an extended-release form to improve focus and manage behavior.

  • Generic versions of Adderall XR, available since 2012, offer the same active ingredients and efficacy at a lower cost, making treatment more accessible.

  • Differences between brand-name and generic Adderall XR include appearance, inactive ingredients, and costs.

  • Off-label uses of Adderall XR include treatment-resistant depression, weight loss, and boosting cognitive functions despite potential risks and lack of FDA approval for these uses.

In this article:

Adderall XR is a central nervous system (CNS) stimulant prescribed to manage attention deficit hyperactivity disorder (ADHD). It contains four amphetamine salts: dextroamphetamine sulfate, amphetamine sulfate, dextroamphetamine saccharate, and amphetamine (D, L)-aspartate monohydrate. It works by increasing natural substances within the brain, which may help improve the ability to focus, stay attentive, and manage impulsive behavior. 

Following its approval by the U.S. Food and Drug Administration (FDA) in 2001, Adderall XR has become a popular medication for managing symptoms of ADHD. A generic version of Adderall XR has been available in the U.S. since 2012. 

Generic Adderall XR vs. brand-name Adderall XR

Generic Adderall XR contains amphetamine and dextroamphetamine and works the same way as the brand-name drug. Companies like Sun Pharmaceuticals, Impax Laboratories, and Takeda Pharmaceuticals manufacture it. While generic and brand-name Adderall XR are equally effective and contain the same active ingredients, they differ in a few ways:

  • Appearance: Brand-name Adderall XR capsules are usually bright blue or orange and have unique markings that help identify them. Generic versions may differ in color and markings.
  • Inactive ingredients: These ingredients do not have any medicinal effects and can include fillers, binders, preservatives, and coloring agents. Since inactive ingredients can vary between different manufacturers, generic versions may differ in the appearance or texture of the capsules. For people with allergies or sensitivities, these differences might affect how well they tolerate the medication.
  • Cost: A major benefit of generic Adderall XR is that it’s typically cheaper than the brand-name version. A lower price can make it a more affordable option for many people, increasing access to the drug without sacrificing quality.

Even though generic and brand-name Adderall XR work the same, some people may report feeling a difference in effectiveness. These perceptions may be influenced by expectations or slight variations in inactive ingredients. However, generic versions are closely regulated and must meet the same quality standards as brand-name drugs. Therefore, both types should provide similar results in managing ADHD symptoms.

RELATED: Adderall XR dosage, forms, and strengths

How much is generic Adderall XR?

Although the cost of generic Adderall XR can be much less than its brand-name counterpart, the average price per prescription without insurance can fluctuate depending on the dosage and quantity prescribed. 

The average retail price of a 30-day supply of 30 mg Adderall XR capsules is around $345, while the average retail price for the same supply of the generic version may be lower. Local pharmacy chains, independent drugstores, and online pharmacies may offer different pricing for brand-name and generic versions of Adderall XR. Factors such as location, available pharmacy benefits, and even the time of year can impact the overall cost. In addition, negotiations between pharmacies and manufacturers might result in variable pricing.

Prescription discount cards and coupon programs, like those provided by SingleCare, may help provide savings on the retail cost. These discount cards may sometimes offer competitive prices compared to paying out-of-pocket, especially for people without insurance coverage.

Brand vs. generic Adderall XR prices
Brand-name Adderall XR Adderall XR generic (amphetamine-dextroamphetamine ER)
Average cost without insurance $345 for 30, 30 mg capsules of Adderall XR $254 for 30, 30 mg capsules, of amphetamine-dextroamphetamine
SingleCare’s lowest price $28 for 30, 30 mg capsules of Adderall XR $28 for 30, 30 mg capsules of amphetamine-dextroamphetamine XR
Free coupons Adderall XR coupons Amphetamine-dextroamphetamine coupons

RELATED: How much is Adderall XR without insurance?

How to switch from Adderall XR to amphetamine-dextroamphetamine ER

In many cases, healthcare providers will prescribe generic versions of medications to help reduce patient costs. Sometimes, a healthcare provider may prescribe the brand-name version. If you or a loved one takes the brand-name version and wants to switch to the generic equivalent, consult a healthcare provider for medical advice. The process generally includes the following:

  • Consultation with a healthcare provider: Before making any changes, you should discuss the switch with a doctor, as generic versions may contain different inactive ingredients you may be sensitive to.
  • Maintain the medication schedule: You’ll likely be prescribed to take your first dose of amphetamine-dextroamphetamine ER at the same time you would usually take Adderall XR to maintain the dosing schedule.
  • Prevent disruption: To prevent any lapse in treatment, ensure you have the new prescription before the current medication runs out.
  • Watch for side effects: After you switch medications, read the medication guide and pay attention to any new or unusual symptoms. Let your doctor know if you experience persistent or worsening side effects.
  • Schedule follow-up appointments: Depending on how your body reacts to the new medicine, you might need a different amount. Regular check-ins with your doctor will help ensure you’re on the right dose.
  • Consider your lifestyle: Talk to your doctor about any changes you can make in your daily life that might help the new medicine work better, like improving your diet, getting more exercise, or ensuring you sleep well.
  • Don’t stop suddenly: Don’t stop taking stimulant medication all at once without talking to your doctor first. Stopping suddenly can cause withdrawal symptoms, such as depression, agitation, and tiredness.

Adderall XR, in any form, is a controlled substance that may have a high potential for dependence and misuse. Transitioning from Adderall XR to amphetamine-dextroamphetamine ER is a process that should always be guided by a healthcare provider. 

Other things to consider while taking amphetamine-dextroamphetamine ER

Both brand-name Adderall XR and generic amphetamine-dextroamphetamine ER can cause side effects, some of which can be serious. Most side effects might occur during the first few weeks of treatment, with many people experiencing mild or no side effects. The severity can depend on the person and dosage. Common side effects may include:

  • Loss of appetite
  • Trouble sleeping
  • Dry mouth
  • Nervousness
  • Weight loss
  • Stomach pain
  • Nausea

Serious side effects of Adderall XR include misuse and addiction, especially in those with a history of drug abuse, blurred vision, serotonin syndrome, and mental health problems such as worsened behavior or thought problems, psychosis, and mania. In addition, sudden death in people with a history of heart problems or serious heart disease has been reported in clinical studies. 

Before starting treatment with amphetamine-dextroamphetamine ER, it’s important to tell your healthcare provider if you have certain health conditions, such as:

  • Heart problems, including an enlarged heart, serious heart rate problems, or heart disease
  • High blood pressure
  • Hyperthyroidism or other thyroid problems
  • Glaucoma
  • A personal or family history of mental health problems, such as bipolar disorder, depression, or suicidal thoughts
  • A history of drug abuse or addiction
  • Tourette syndrome or tics
  • Pregnancy or breastfeeding

Adderall extended-release capsules may interact with various medications, including antidepressants, blood pressure medications, and certain herbal products. Tell your healthcare provider about all prescription drugs, supplements, and over-the-counter medications you take to avoid potentially harmful interactions.

Amphetamine-dextroamphetamine ER alternatives

If you experience problems with generic Adderall XR, such as concerns about cost or troubling side effects, other medications may be recommended. Alternatives to Adderall XR generally fall into two categories: stimulants and non-stimulants. These alternatives may come in different dosage forms and may help manage ADHD in different ways. 

Stimulant alternatives to Adderall XR

Stimulants are medications typically prescribed to treat ADHD because they increase certain chemicals in the brain, such as dopamine and norepinephrine, improving attention and reducing impulsivity. While stimulants are generally effective, they may share similar side effects or risks as Adderall XR. Common stimulant alternatives include:

  • Vyvanse (lisdexamfetamine): This long-acting stimulant remains effective throughout the day and is prescribed for ADHD or binge eating disorder.
  • Focalin XR (dexmethylphenidate ER): This drug contains only the active form of methylphenidate, potentially leading to fewer side effects and improved focus.
  • Ritalin LA (methylphenidate ER): Ritalin LA capsules can deliver immediate-release effects followed by sustained symptom control throughout the day.
  • Daytrana (methylphenidate transdermal system): Daytrana is a patch that provides a steady release of medication throughout the day and may be preferred for those avoiding oral medications.

Non-stimulant alternatives to Adderall XR

Non-stimulant medications can be alternatives for people who are unable to use stimulant medications or have health problems that make stimulants unsafe. They can also be used in addition to stimulants as part of a combination treatment plan. These medications work differently from stimulant drugs and usually have a lower risk of being misused or causing dependency. Examples of non-stimulant medications include:

  • Strattera (atomoxetine): This selective norepinephrine reuptake inhibitor can help improve focus and reduce impulsive behavior without the stimulant effects.
  • Intuniv (guanfacine ER): This extended-release medication was initially developed to treat high blood pressure but is now approved to manage symptoms of ADHD.
  • Kapvay (clonidine ER): Similar to Intuniv, the active ingredient of this medication can be used to treat high blood pressure but is also approved to manage ADHD alone or with stimulant medications.
  • Qelbree (viloxazine ER): Qelbree recently received FDA approval to help control attention deficits and hyperactivity through a mechanism different from traditional stimulants.

Your healthcare provider can help you explore alternative options if needed. They can review your overall condition and help find a medication that controls ADHD symptoms while managing costs and reducing unwanted side effects.