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AI-Generated Summary This article by infectious diseases pharmacist Aneeka Chavda outlines five key considerations for pharmacists in the treatment of Mycobacterium tuberculosis (TB), particularly drug-sensitive cases. The piece advocates for therapeutic drug monitoring (TDM) in specific high-risk groups to personalize treatment.
Tarlatamab established a new standard for relapsed SCLC, with improved survival and easier administration, enhancing treatment accessibility. 2 Vepdegestrant is an oral PROTAC that targets ER and is the first agent of its type to be evaluated in a phase 3 trial.
Image credit: OM | stock.adobe.com Why Proper Disposal Matters Disposing of medications appropriately helps prevent environmental contamination of water and soil. Safe disposal options include DEA Take Back Days, pharmacy kiosks, law enforcement kiosks, mail-back envelopes, and home disposal methods.
Malesker, PharmD, FCCP, FCCM, FASHP, BCPS +1 More Hypertension is widespread and linked to serious health risks, but new treatments for resistant cases target new mechanisms of action. Jansen, PharmD Candidate , Mark A. 2,3 Hypertension remains a major public health challenge both in the United States and globally.
SHOW MORE Pharmacists can help oversee the treatment process to ensure patients with transthyretin amyloid cardiomyopathy (ATTR-CM) are adhering to tafamidis. Ongoing research explores tafamidis' long-term efficacy, potential in other heart failure forms, and combination therapies for enhanced outcomes.
Although the use of colony-stimulating factors (CSFs) is well-established in mitigating severe FN, existing literature suggests there is only an approximate 3% difference in FN rates between various CSF agents. Utilizing colony-stimulating factors (CSFs) decreases the incidence of severe FN.
3 Although meloxicam injection delivers a non-opioid alternative for pain control, it is not recommended as a first-line agent when rapid onset of analgesia is needed due to its delayed onset. 2 REFERENCES 1. Meloxicam: Selective COX-2 inhibition in clinical practice. Seminars in Arthritis and Rheumatism. December 21, 2004. Subscribe Now!
Cardiovascular disease risks in HIV patients have evolved with ART, requiring preventive measures like statins and cardiovascular risk scores for effective management. Healthy aging in HIV patients involves addressing accelerated aging, multimorbidity, and geriatric syndromes, emphasizing functional ability and quality of life.
The presentation emphasized early intervention and personalized treatment plans in managing type 2 diabetes, shifting from "treating to failure" to "treating to target." He was joined by Laura, a patient who began tirzepatide treatment shortly after being diagnosed with T2D.
Further research is needed on the clinical impact, treatment longevity, and cost implications of biosimilar use in pediatric IBD. SHOW MORE The study found biosimilar initiation rose to nearly 42% from 2016 to 2023. Anti-TNFs remain the only FDA-approved class for pediatric IBD, prompting biosimilar use for cost and accessibility.
Understanding and addressing barriers to medication adherence are crucial for effective treatment of psychiatric disorders and improving patient outcomes. Reviewing Medication Adherence According to the WeAllCount Census for 2022 to 2023, 6 homelessness in San Diego increased by 22% (from 8427 to 10,264 individuals).
Gilead’s recently approved drug for HIVprevention, Yeztugo (lenacapavir), has the potential to transform the pre-exposure prophylaxis (PrEP) sector in the US, according to market analysts. Go deeper with GlobalData Reports LOA and PTSR Model - BRII-732 in Human Immunodeficiency Virus (HIV).
She emphasizes that treatment options are mostly supportive, making prevention through good hygiene and vaccination essential. As a result, RSV is often overlooked as a contributing agent to respiratory and especially cardiorespiratory disease.
The US Food and Drug Administration (FDA) has placed a clinical hold on several of Gilead’s trials evaluating two HIVtreatment candidates, though the rest of the drugmaker’s diverse pipeline remains unaffected. Gilead is considered the leading big pharma in HIVtreatments. Shares in Nasdaq-listed Gilead opened 0.3%
Upon sensing dsRNA, the cell effectively halts protein synthesis, thereby preventing the virus from manufacturing the essential proteins required for its own reproduction. This innovative approach allowed for the high-throughput screening of many compounds, specifically 370,830, to discover potential therapeutic agents. EuerkAlert!
million deaths in 2023. Despite longstanding knowledge that TB is both preventable and curable, progress has stalled. He took aim at the diagnostic and preventive tools that have defined TB control for decades: the Bacillus Calmette-Guérin vaccine, Ziehl-Neelsen staining, microscopy and the tuberculin skin test.
This drug is currently in multiple P-IIa clinical trials and is being evaluated in combination with other antiviral agents for cHBV. ARO-AAT and ARO-APOC3 are among the highest-phase products developing under Arrowhead’s pipeline for the treatment of liver diseases. R&D Expenditure: $85.1M R&D Expenditure: $437.9M
1 , 4 A Retrospective Journey In 2015, Vertex’s Orkambi was the first approved drug produced under a CM process for the treatment of cystic fibrosis. Pharma Investment Trend Report: What We’re Watching in 2023.” Published 13 January 2023. Updated 10 January 2023. This is demonstrated by the rise from $1.05 Zydney, and J.
And as we’ve seen, even with supplementation, you need to address your root causes to prevent iron supply and demand challenges. Viruses that have been associated with anemia include Epstein-Barr Virus , hepatitis A and C, human herpes virus 6 (HHV-6), cytomegalovirus, parvovirus B19, and HIV. [45] However, when they added 1.5
Nikolai Lazarev defined adaptogens as “an agent that raises the body’s ability to resist stress by countering undesired stressors, whether physical, chemical, emotional, or biological.” Would you like to know if adaptogenic herbs might be of benefit to you? This can also mean fewer nutrients are absorbed.
With Twitter changing to X in mid-2023 and subsequently in the end of 2024 many folks from the IDtwitter community moving over to Bluesky, the game is certainly ever-changing. HIV incidence with lenacapavir was significantly lower than background HIV incidence and HIV incidence with daily oral F/TDF. Gauthier, Pharm.D.,
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